Murphy D L, Costa J L, Shafer B, Corash L
Psychopharmacology (Berl). 1978 Oct 31;59(2):193-7. doi: 10.1007/BF00427757.
Monoamine oxidase (MAO) activity measured in human platelets is reportedly altered by such drugs as epinephrine, lithium carbonate, and imipramine, and also reduced in a number of clinical disorders. To evaluate whether MAO activity might differ in platelet subpopulations, density gradient centrifugation with arabino-galactan was used to prepare four platelet fractions that differed in weight and volume. MAO activity in the lightest and smallest platelet subpopulation was approximately one-half that in the heaviest and largest subpopulation. Because platelet weight and size are thought to be related to platelet age, it is possible that some drug effects on platelet MAO activity might represent changes in platelet turnover. Factors other than platelet turnover rates may contribute to individual differences in platelet MAO activity, however, since one group of individuals with markedly reduced platelet MAO activity exhibited no shift in the proportion of lighter versus heavier platelets nor in the relative amount of MAO activity in each density gradient subfraction.
据报道，诸如肾上腺素、碳酸锂和丙咪嗪等药物会改变在人体血小板中测得的单胺氧化酶（MAO）活性，并且在一些临床病症中MAO活性也会降低。为了评估MAO活性在血小板亚群中是否存在差异，使用阿拉伯半乳聚糖进行密度梯度离心来制备四个在重量和体积上不同的血小板组分。最轻且最小的血小板亚群中的MAO活性约为最重且最大的亚群中的一半。由于血小板重量和大小被认为与血小板年龄有关，因此某些药物对血小板MAO活性的影响可能代表血小板更新的变化。然而，除血小板更新率之外的因素可能导致血小板MAO活性的个体差异，因为一组血小板MAO活性明显降低的个体在较轻与较重血小板的比例以及每个密度梯度亚组分中MAO活性的相对量方面均未出现变化。
