Bergmann H, Kolarz G
Eur J Nucl Med. 1976 Dec 30;1(4):205-10. doi: 10.1007/BF00252165.
A new isotopic method for evaluation of inflammatory activity in rheumatoid arthritis is reported. By use of repeated whole body profile scanning a double tracer examination with 99mTc-pertechnetate and 113mIn-transferrin was performed. Total pertechnetate activity and total indium activity were measured over both hands, both feet, the ankles, and over the knee joints. In addition, the extravascular component of pertechnetate uptake and the ratio extravascular/total pertechnetate activity were calculated for these regions. The activity curves were followed up to 2 h after tracer injection in seven female patients presenting with rheumatoid arthritis and in six female controls. The four parameters calculated were compared and statistical analysis revealed the most significant discrimination of both groups for the ratio extravascular/total pertechnetate activity 2 h after injection (P less than 0.002).
报道了一种评估类风湿性关节炎炎症活动的新同位素方法。通过重复进行全身轮廓扫描，采用99m锝高锝酸盐和113m铟转铁蛋白进行双示踪剂检查。测量双手、双足、踝关节和膝关节的总高锝酸盐活性和总铟活性。此外，还计算了这些区域高锝酸盐摄取的血管外成分以及血管外/总高锝酸盐活性的比值。在7名患有类风湿性关节炎的女性患者和6名女性对照中，在示踪剂注射后对活性曲线进行了长达2小时的跟踪。对计算出的四个参数进行了比较，统计分析显示，注射后2小时血管外/总高锝酸盐活性比值对两组的区分最为显著（P小于0.002）。
