mRNA中的外显子重复。
Exon repetition in mRNA.
作者信息
Frantz S A, Thiara A S, Lodwick D, Ng L L, Eperon I C, Samani N J
机构信息
Department of Cardiology, University of Leicester, Leicester LE3 9QP, United Kingdom.
出版信息
Proc Natl Acad Sci U S A. 1999 May 11;96(10):5400-5. doi: 10.1073/pnas.96.10.5400.
Abstract
The production of different transcripts (transcript heterogeneity) is a feature of many genes that may result in phenotypic variation. Several mechanisms, that occur at both the DNA and RNA level have been shown to contribute to this transcript heterogeneity in mammals, all of which involve either the rearrangement of sequences within a genome or the use of alternative signals in linear, contiguous DNA or RNA. Here we describe tissue-specific repetition of selective exons in transcripts of a rat gene (SA) with a normal exon-intron organization. We conclude that nonlinear mRNA processing can generate tissue-specific transcripts.
摘要
不同转录本的产生（转录本异质性）是许多基因的一个特征，这可能导致表型变异。在DNA和RNA水平上发生的几种机制已被证明与哺乳动物中的这种转录本异质性有关，所有这些机制都涉及基因组内序列的重排或线性、连续的DNA或RNA中替代信号的使用。在这里，我们描述了一个具有正常外显子-内含子结构的大鼠基因（SA）转录本中选择性外显子的组织特异性重复。我们得出结论，非线性mRNA加工可以产生组织特异性转录本。
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