灵长类动物中的主要组织相容性复合体I类基因：与病原体的共同进化。

Major histocompatibility complex class I genes in primates: co-evolution with pathogens.

作者信息

Vogel T U, Evans D T, Urvater J A, O'Connor D H, Hughes A L, Watkins D I

机构信息

Wisconsin Regional Primate Research Center, University of Wisconsin, Madison 53715-1299, USA.

出版信息

Immunol Rev. 1999 Feb;167:327-37. doi: 10.1111/j.1600-065x.1999.tb01402.x.

DOI:10.1111/j.1600-065x.1999.tb01402.x

PMID:10319271

Abstract

The major histocompatibility complex (MHC) is the most polymorphic genetic system known, playing a central role in the cellular immune response to pathogens. The relationship between the MHC of humans and non-human primates has increased our understanding of MHC evolution and how polymorphism of this gene family may have been generated. We will review MHC class I evolution in great apes and Old World and New World primates and discuss new data from the simian immunodeficiency virus/rhesus monkey animal model that demonstrate the role of MHC class I alleles in selecting for new populations of viruses. This suggests that certain pathogens co-evolve with the MHC class I molecules they encounter in a population.

摘要

主要组织相容性复合体（MHC）是已知的最具多态性的遗传系统，在针对病原体的细胞免疫反应中发挥核心作用。人类与非人类灵长类动物的MHC之间的关系增进了我们对MHC进化以及该基因家族多态性可能如何产生的理解。我们将回顾大猩猩、旧世界猴和新世界猴中MHC I类分子的进化，并讨论来自猿猴免疫缺陷病毒/恒河猴动物模型的新数据，这些数据证明了MHC I类等位基因在选择新病毒群体方面的作用。这表明某些病原体与它们在种群中遇到的MHC I类分子共同进化。