Viñas F C, Ferris D, Kupsky W J, Dujovny M
Department of Neurological Surgery, Wayne State University, Henry Ford Hospital, Detroit, MI, USA.
Neurol Res. 1999 Apr;21(3):262-8. doi: 10.1080/01616412.1999.11740929.
A comparative animal experimental study was performed to test the potential application of expanded polytetrafluoroethylene (ePTFE) vs. polydioxanone (PDS) as dural substitutes. Sixty male Sprague-Dawley rats underwent a right frontoparietal craniotomy, opening of the dura mater, and a small cortical lesion. The dural defect was covered with a piece of ePTFE or PDS. Animals were sacrificed at 30 days or 90 days. Following decalcification, heads including scalp, skull, and underlying brain were sectioned, stained with hematoxylin-eosin, and histologically analyzed. Dural defects repaired with ePTFE, showed minimal reactive changes and no adhesions to the brain surface. No foreign body type giant cell reaction was seen, and the graft became enclosed in a thin sheet of connective tissue. Dural defects repaired with PDS, showed some giant cell infiltration and ingrowth of collagen fibers. Both substitutes provided satisfactory biological function and biocompatibility. Expanded PTFE advantages included relative suppression of tissue ingrowth, ensheathment by connective tissue, and a high tearing strength. Although both materials show promise for use in dural grafting, further clinical studies are necessary to determine their potential applications as a human dural substitute.
进行了一项对比动物实验研究，以测试膨体聚四氟乙烯（ePTFE）与聚二氧六环酮（PDS）作为硬脑膜替代物的潜在应用。60只雄性Sprague-Dawley大鼠接受了右额顶部开颅手术、硬脑膜切开术和一个小的皮质损伤。硬脑膜缺损处用一片ePTFE或PDS覆盖。在30天或90天时处死动物。脱钙后，将包括头皮、颅骨和下方脑组织的头部切片，用苏木精-伊红染色，并进行组织学分析。用ePTFE修复的硬脑膜缺损显示出最小的反应性变化，且与脑表面无粘连。未见异物型巨细胞反应，移植物被包裹在一层薄的结缔组织中。用PDS修复的硬脑膜缺损显示出一些巨细胞浸润和胶原纤维向内生长。两种替代物均提供了令人满意的生物学功能和生物相容性。膨体聚四氟乙烯的优点包括相对抑制组织向内生长、被结缔组织包裹以及高撕裂强度。尽管两种材料在硬脑膜移植方面都有应用前景，但仍需要进一步的临床研究来确定它们作为人类硬脑膜替代物的潜在应用。
