Hashimoto K, Tsukada T, Matsuda H
Recent Adv Stud Cardiac Struct Metab. 1976;11:451-5.
In the isolated blood-perfused canine ventricular tissue, antiarrhythmic agents could be classified as having: 1) positive chronotropic and inotropic effects (procainamide), 2) negative chronotropic but positive inotropic effects (quinidine), and 3) negative chronotropic and inotropic effects (lidocaine, ajmaline, diphenylhydantoin, and propranolol).
在离体血液灌注的犬心室组织中，抗心律失常药物可分为以下几类：1）具有正性变时性和变力性作用（普鲁卡因胺），2）具有负性变时性但正性变力性作用（奎尼丁），以及3）具有负性变时性和变力性作用（利多卡因、阿吗灵、苯妥英和普萘洛尔）。
