Seyama L, Irisawa H, Honda T, Takeda T, Miwatani T
Recent Adv Stud Cardiac Struct Metab. 1976;11:621-5.
The effects of purified thermostable direct hemolysin from the cultured filtrate of Vibrio parahaemolyticus on both S-A node cells and atrial cells were studied electrophysiologically. Hemolysin caused the membrane conductance to increase, thereby causing membrane depolarization. The major ion responsible for this depolarization was Na+, but other ions, such as K+ and Ca2+, also participated. Positive inotropic action of hemolysin was observed, and the Na-Ca exchange mechanism was enhanced after hemolysin treatment.
用电生理学方法研究了从副溶血性弧菌培养滤液中纯化的耐热直接溶血素对窦房结细胞和心房细胞的作用。溶血素导致膜电导增加，从而引起膜去极化。导致这种去极化的主要离子是Na +，但其他离子，如K +和Ca2 +也参与其中。观察到溶血素具有正性肌力作用，溶血素处理后钠钙交换机制增强。
