Sezai A, Shiono M, Orime Y, Hata H, Yagi S, Tsukamoto S, Kimura S, Hata M, Kashiwazaki S, Cho S, Negishi N, Sezai Y
Second Department of Surgery, Nihon University School of Medicine, Tokyo, Japan.
Kyobu Geka. 1999 May;52(5):384-9.
In this study, we used alpha-human atrial natriuretic peptide (hANP) from staring on cardiopulmonary bypass and evaluated for the hemodynamics, ANP, renin activity, aldosterone, urine volume, glomerular filtration rate (GFR) and so on. The hANP decreased renin activity, aldosterone, systemic vascular resistance and increased urine volume, GFR and use of furosemide and KCL were decreased. We concluded that hANP was effective for hemodynamics, renal function and hormonal release on intra and post-operation in cardiac surgery, and low dose continuous infusion of alpha-hANP from staring on cardiopulmonary bypass will be expected as a newly application.
