心力衰竭时心脏去甲肾上腺素释放对等长握力运动的反应降低。

Reduced response of cardiac norepinephrine release to isometric handgrip exercise in heart failure.

作者信息

Haneda T, Miura Y, Miyazawa K, Sato T, Shirato K, Honna T, Nakajima T, Arai T, Kobayashi K, Sakuma H, Yoshinaga K, Takishima T

出版信息

Recent Adv Stud Cardiac Struct Metab. 1976;12:383-7.

PMID:1031990

Abstract

In order to evaluate the relation of cardiac norepinephrine (NE) release to left ventricular function, blood was taken simultaneously from the coronary sinus (CS) and the aorta (A) in 19 patients with heart diseases, at rest and during isometric handgrip exercise (IHG) at 30% of their maximal contraction. Plasma NE was analyzed by Renzini's THI method. The concentrations of plasma NE at rest were 397 +/- 66 (S.E.M.) ng/liter in CS and 292 +/- 50 in A. IHG significantly increased NE to 578 +/- 88 in CS and to 462 +/- 85 in A (p less than 0.001). Estimated NE release from the heart (deltaNE = NECS - NEA) correlated inversely to left ventricular end-diastolic pressure at rest (r = -0.520, p less than 0.05) and during IHG (r= -0.689, p less than 0.01). The changes in deltaNE induced by IHG correlated to the slope of the left ventricular function curve (r=0.618, p less than 0.01). It is concluded that the response of cardiac NE release to exercise is reduced in patients with depressed cardiac function.

摘要

为了评估心脏去甲肾上腺素（NE）释放与左心室功能的关系，对19例心脏病患者在静息状态下以及在最大收缩力30%的等长握力运动（IHG）期间，同时从冠状窦（CS）和主动脉（A）采集血液。采用伦齐尼的THI法分析血浆NE。静息时CS中血浆NE浓度为397±66（标准误）ng/升，A中为292±50 ng/升。等长握力运动使CS中NE显著增加至578±88 ng/升，A中增加至462±85 ng/升（p<0.001）。估计心脏释放的NE（ΔNE = NECS - NEA）与静息时（r = -0.520，p<0.05）和等长握力运动期间（r = -0.689，p<0.01）的左心室舒张末期压力呈负相关。等长握力运动引起的ΔNE变化与左心室功能曲线的斜率相关（r = 0.618，p<0.01）。结论是心功能不全患者心脏NE释放对运动的反应降低。