Akhondzadeh S, Mohammadi M R, Amini-Nooshabadi H, Davari-Ashtiani R
Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Iran.
J Clin Pharm Ther. 1999 Feb;24(1):49-52. doi: 10.1046/j.1365-2710.1999.00197.x.
There is growing interest in investigating the role of 5-HT receptors in the physiopathology of schizophrenia in particular the negative symptoms. Indeed, newer atypical antipsychotics which interact with 5-HT receptors are more effective in the treatment of negative symptoms compared to typical neuroleptics. We undertook a trial to investigate whether the combination of haloperidol with cyproheptadine, a relatively safe serotonin-blocking agent was more effective than haloperidol alone.
Thirty patients who met the DSM IV criteria for chronic schizophrenia completed the study. Patients were allocated in a random fashion, 15 each to haloperidol 30 mg/day plus cyproheptadine 24 mg/ day and haloperidol 30 mg/day plus placebo.
Although both protocols significantly decreased the positive and negative symptom score over the trial period, the combination of haloperidol and cyproheptadine showed significant superiority over haloperidol alone in the treatment of the negative symptoms.
Cyproheptadine is a relatively safe compound and may be of therapeutic benefit in treating negative symptoms of schizophrenia in combination with typical neuroleptics. However, a larger study to confirm our results is warranted.
人们越来越关注研究5-羟色胺（5-HT）受体在精神分裂症生理病理学中的作用，尤其是在阴性症状方面。事实上，与5-HT受体相互作用的新型非典型抗精神病药物在治疗阴性症状方面比典型抗精神病药物更有效。我们进行了一项试验，以研究氟哌啶醇与相对安全的血清素阻断剂赛庚啶联合使用是否比单独使用氟哌啶醇更有效。
30名符合DSM-IV慢性精神分裂症标准的患者完成了该研究。患者被随机分配，15名接受氟哌啶醇30毫克/天加赛庚啶24毫克/天，15名接受氟哌啶醇30毫克/天加安慰剂。
尽管在试验期间两种方案均显著降低了阳性和阴性症状评分，但氟哌啶醇和赛庚啶联合使用在治疗阴性症状方面比单独使用氟哌啶醇显示出显著优势。
赛庚啶是一种相对安全的化合物，与典型抗精神病药物联合使用可能对治疗精神分裂症的阴性症状有益。然而，需要进行更大规模的研究来证实我们的结果。
