庚醇对罗马蜗牛颊神经节中已鉴定的神经元产生癫痫样效应。
Heptanol exerts epileptiform effects in identified neurons of the buccal ganglia of Helix pomatia.
作者信息
Tarner I H, Altrup U, Speckmann E J
机构信息
Institut für Experimentelle Epilepsieforschung, Universität Münster, Germany.
出版信息
Neurosci Lett. 1999 Apr 2;264(1-3):73-6. doi: 10.1016/s0304-3940(99)00173-1.
1-Heptanol (0.2-5.0 mM) known to block electrical contacts was tested under epileptic and non-epileptic conditions in the buccal ganglia of Helix pomatia. Synchronicity of epileptiform activity was not affected. In concentrations below 1 mM, heptanol accelerated epileptiform activity induced by pentylenetetrazol. In concentrations above 1 mM, it evoked epileptiform activity without admixture of an epileptogenic drug. Coupling coefficient was increased and decreased in low and high concentration ranges of heptanol, respectively. The measured decrease of coupling is interpreted as a result of the activation of 'epileptiform' membrane conductances accompanied by decreased length constants of neuronal fibers.
已知可阻断电接触的正庚醇（0.2 - 5.0毫摩尔）在癫痫和非癫痫状态下，于苹果螺的颊神经节中进行了测试。癫痫样活动的同步性未受影响。在浓度低于1毫摩尔时，正庚醇加速了由戊四氮诱导的癫痫样活动。在浓度高于1毫摩尔时，它在未混合致痫药物的情况下诱发了癫痫样活动。耦合系数在正庚醇的低浓度和高浓度范围内分别增加和降低。测得的耦合降低被解释为“癫痫样”膜电导激活的结果，同时伴有神经元纤维长度常数的降低。
Zotero 插件