5-羟色胺1A受体的刺激选择性地抑制大鼠视觉皮层中N-甲基-D-天冬氨酸受体介导的突触兴奋。

Stimulation of the 5-HT1A receptor selectively suppresses NMDA receptor-mediated synaptic excitation in the rat visual cortex.

作者信息

Edagawa Y, Saito H, Abe K

机构信息

Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

出版信息

Brain Res. 1999 May 8;827(1-2):225-8. doi: 10.1016/s0006-8993(99)01300-1.

DOI:10.1016/s0006-8993(99)01300-1

PMID:10320714

Abstract

We have previously found that stimulation of serotonin 5-HT1A receptors inhibits the induction of long-term potentiation (LTP) in the rat visual cortex. In the present study, the selective 5-HT1A receptor agonist 8-hydroxy-2-(N,N-dipropylamino)tetralin (8-OH-DPAT) significantly reduced N-methyl-d-aspartate (NMDA) receptor-mediated synaptic responses recorded in Mg2+-free medium in rat visual cortical slices. In addition, there was good correlation between the inhibitory effects of 8-OH-DPAT on NMDA responses and LTP. These results suggest that 5-HT1A receptor stimulation inhibits the induction of LTP by suppressing NMDA receptor-mediated synaptic excitation in the rat visual cortex.

摘要

我们之前发现，刺激5-羟色胺5-HT1A受体可抑制大鼠视觉皮层中长时程增强（LTP）的诱导。在本研究中，选择性5-HT1A受体激动剂8-羟基-2-（N，N-二丙基氨基）四氢萘（8-OH-DPAT）显著降低了在无镁培养基中记录的大鼠视觉皮层切片中N-甲基-D-天冬氨酸（NMDA）受体介导的突触反应。此外，8-OH-DPAT对NMDA反应的抑制作用与LTP之间存在良好的相关性。这些结果表明，刺激5-HT1A受体通过抑制大鼠视觉皮层中NMDA受体介导的突触兴奋来抑制LTP的诱导。