School of Medicine, Cardiff University, UK.
Nat Rev Neurol. 2012 Nov 5;8(11):635-46. doi: 10.1038/nrneurol.2012.179.
The development of therapeutic strategies that promote functional recovery is a major goal of multiple sclerosis (MS) research. Neuroscientific and methodological advances have improved our understanding of the brain's recovery from damage, generating novel hypotheses about potential targets and modes of intervention, and laying the foundation for development of scientifically informed recovery-promoting strategies in interventional studies. This Review aims to encourage the transition from characterization of recovery mechanisms to development of strategies that promote recovery in MS. We discuss current evidence for functional reorganization that underlies recovery and its implications for development of new recovery-oriented strategies in MS. Promotion of functional recovery requires an improved understanding of recovery mechanisms that can be modulated by interventions and the development of robust measurements of therapeutic effects. As imaging methods can be used to measure functional and structural alterations associated with recovery, this Review discusses their use to obtain reliable markers of the effects of interventions.
促进功能恢复的治疗策略的发展是多发性硬化症（MS）研究的主要目标。神经科学和方法学的进步提高了我们对大脑从损伤中恢复的理解，为潜在的靶点和干预模式产生了新的假设，并为干预研究中开发基于科学的促进恢复策略奠定了基础。本综述旨在鼓励从恢复机制的表征转向 MS 中促进恢复的策略的发展。我们讨论了目前关于功能重组的证据，这些证据是恢复的基础，对开发新的以恢复为导向的 MS 策略具有启示意义。促进功能恢复需要更好地理解可以通过干预来调节的恢复机制，并开发出对治疗效果进行可靠测量的方法。由于成像方法可用于测量与恢复相关的功能和结构改变，因此本综述讨论了它们在获得干预效果的可靠标志物方面的应用。
