外周T细胞存活
Peripheral T cell survival.
作者信息
Freitas A A, Rocha B
机构信息
Laboratoire des Dynamiques Lymphocytaires, CNRS 1961, Institut Pasteur, 28 Rue du Dr Roux, 75015, Paris, France.
出版信息
Curr Opin Immunol. 1999 Apr;11(2):152-6. doi: 10.1016/s0952-7915(99)80026-0.
Abstract
T cell survival in the periphery is an active process, depending on continuous TCR engagement by peptide-MHC complexes and/or response to environmental cytokines. Naive T cells require interactions with the MHC restricting element. The survival requirements of memory T cells are as yet insufficiently characterized, but MHC-restricted interactions are not necessary.
摘要
外周T细胞的存活是一个活跃的过程，依赖于肽 - 主要组织相容性复合体（peptide-MHC complexes）持续的T细胞受体（TCR）结合以及/或者对环境细胞因子的反应。初始T细胞需要与MHC限制元件相互作用。记忆T细胞的存活需求尚未得到充分表征，但MHC限制的相互作用并非必需。
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