Hypermutation in antibody affinity maturation.
作者信息
Wabl M, Cascalho M, Steinberg C
机构信息
Department of Microbiology and Immunology, University of California, San Francisco, CA 94143-0670, USA.
出版信息
Curr Opin Immunol. 1999 Apr;11(2):186-9. doi: 10.1016/s0952-7915(99)80031-4.
Abstract
By studying the role of mismatch repair in hypermutation at the immunoglobulin loci, the field of antibody hypermutation has been integrated into the larger area of DNA repair. Trans-acting factors - Ku70, Ku80 and possibly SWAP-70 - have been identified for the temporally related but not mechanistically related immunoglobulin heavy-chain class-switch.
摘要
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