Stülke J, Hillen W
Lehrstuhl für Mikrobiologie, Institut für Mikrobiologie, Biochemie und Genetik der Friedrich-Alexander-Universität, Erlangen-Nüurnberg, Staudtstr.5, D-91058, Erlangen, Germany.
Curr Opin Microbiol. 1999 Apr;2(2):195-201. doi: 10.1016/S1369-5274(99)80034-4.
Carbon catabolite repression (CCR) is a regulatory mechanism by which the expression of genes required for the utilization of secondary sources of carbon is prevented by the presence of a preferred substrate. This enables bacteria to increase their fitness by optimizing growth rates in natural environments providing complex mixtures of nutrients. In most bacteria, the enzymes involved in sugar transport and phosphorylation play an essential role in signal generation leading through different transduction mechanisms to catabolite repression. The actual mechanisms of regulation are substantially different in various bacteria. The mechanism of lactose-glucose diauxie in Escherichia coli has been reinvestigated and was found to be caused mainly by inducer exclusion. In addition, the gene encoding HPr kinase, a key component of CCR in many bacteria, was discovered recently.
碳分解代谢物阻遏（CCR）是一种调节机制，通过该机制，在存在首选底物的情况下，利用次级碳源所需基因的表达会受到抑制。这使细菌能够通过在提供复杂营养混合物的自然环境中优化生长速率来提高其适应性。在大多数细菌中，参与糖转运和磷酸化的酶在信号产生中起关键作用，通过不同的转导机制导致碳分解代谢物阻遏。不同细菌中的实际调节机制有很大差异。对大肠杆菌中乳糖 - 葡萄糖二次生长现象的机制进行了重新研究，发现其主要由诱导物排除引起。此外，最近还发现了编码HPr激酶的基因，HPr激酶是许多细菌中CCR的关键组成部分。
