DNA结构与转录。
DNA structure and transcription.
作者信息
Dai X, Rothman-Denes L B
机构信息
Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois 60637, USA.
出版信息
Curr Opin Microbiol. 1999 Apr;2(2):126-30. doi: 10.1016/S1369-5274(99)80022-8.
Regulation of transcription occurs through complex interactions of RNA polymerase and accessory proteins with specific DNA sequences and with each other. The DNA template topology influences the interaction of RNA polymerase with the promoter and its response to repressors, activators and the intracellular milieu through the formation of altered DNA structures or of nucleoprotein complexes. Recent developments on the role of DNA structures in transcription regulation are discussed.
转录调控是通过RNA聚合酶和辅助蛋白与特定DNA序列以及它们彼此之间的复杂相互作用来实现的。DNA模板拓扑结构通过形成改变的DNA结构或核蛋白复合物，影响RNA聚合酶与启动子的相互作用及其对阻遏物、激活物和细胞内环境的反应。本文讨论了DNA结构在转录调控中的作用的最新进展。
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