Cox KA, Dunn-Meynell K, Korfmacher WA, Broske L, Nomeir AA, Lin CC, Cayen MN, Barr WH
Department of Drug Metabolism and Pharmacokinetics, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033-0539, USA.
Drug Discov Today. 1999 May;4(5):232-237. doi: 10.1016/s1359-6446(98)01299-9.
In therapeutic areas aimed at developing an orally administered drug, the pharmacokinetic profile of a drug candidate after oral administration in vivo is pivotal in evaluating its success. This can be done by monitoring the plasma concentration versus time after dosing and calculating the area under the curve (AUC). The authors describe a novel screening protocol in which an estimated AUC can be determined, allowing the rapid evaluation of large numbers of compounds and providing a rank order of estimated AUC values to prioritize compounds for further investigation.
