WD重复序列：多种功能的常见结构。

The WD repeat: a common architecture for diverse functions.

作者信息

Smith T F, Gaitatzes C, Saxena K, Neer E J

机构信息

Boston University, Biomolecular Engineering Research Center, Boston, MA 02215, USA.

出版信息

Trends Biochem Sci. 1999 May;24(5):181-5. doi: 10.1016/s0968-0004(99)01384-5.

DOI:10.1016/s0968-0004(99)01384-5

PMID:10322433

Abstract

Our knowledge of the large family of proteins that contain the WD repeat continues to accumulate. The WD-repeat proteins are found in all eukaryotes and are implicated in a wide variety of crucial functions. The solution of the three-dimensional structure of one WD-repeat protein and the assumption that the structure will be common to all members of this family has allowed subfamilies of WD-repeat proteins to be defined on the basis of probable surface similarity. Proteins that have very similar surfaces are likely to have common binding partners and similar functions.

摘要

我们对包含WD重复序列的蛋白质大家族的了解不断积累。WD重复序列蛋白存在于所有真核生物中，并涉及多种关键功能。一种WD重复序列蛋白三维结构的解析以及该结构可能为这个家族所有成员所共有的假设，使得基于可能的表面相似性来定义WD重复序列蛋白的亚家族成为可能。表面非常相似的蛋白质可能具有共同的结合伴侣和相似的功能。