Neer E J, Schmidt C J, Nambudripad R, Smith T F
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Nature. 1994 Sep 22;371(6495):297-300. doi: 10.1038/371297a0.
WD proteins are made up of highly conserved repeating units usually ending with Trp-Asp (WD). They are found in all eukaryotes but not in prokaryotes. They regulate cellular functions, such as cell division, cell-fate determination, gene transcription, transmembrane signalling, mRNA modification and vesicle fusion. Here we define the common features of the repeating units, and criteria for grouping such proteins into functional subfamilies.
WD 蛋白由高度保守的重复单元组成，通常以色氨酸 - 天冬氨酸（WD）结尾。它们存在于所有真核生物中，而不存在于原核生物中。它们调节细胞功能，如细胞分裂、细胞命运决定、基因转录、跨膜信号传导、mRNA 修饰和囊泡融合。在这里，我们定义了重复单元的共同特征，以及将此类蛋白质分组为功能亚家族的标准。
