Puntoni de Mikulic L E, Márquez M T, Aramendía P
Acta Physiol Lat Am. 1976;26(4):254-9.
Isoproterenol and propranolol, in a single dose, caused hyperglycemia after 15 and 30 min, either in the conscious rat or in the anesthetized dog. In this latter species no modifications of the serum potassium were observed. Adrenaline, 5 microgram/kg, iv provoked hyperglycemia at the same intervals and hyperkalemia at min 1st and 2nd with further hypokalemia until 90 min. The beta-adrenergic blocker, sotalol, 5 mg/kg, iv, administered prior to adrenaline suppressed the increase in glycemia and the late decrease in serum potassium, but not the early hyperkalemia. In the isolated hind limb of the dog the intra femoral artery administration of adrenaline, 3 microgram/kg, produced similar hyperglycemia either in the artery or in the femoral vein, starting from the 15 min. Contrarily, the serum concentration of potassium was significantly less in the vein than in the artery at the 1st min. These findings suggest that different receptors are involved in the glucose and potassium response to adrenaline, and the skeletal muscle plays an important role in the regulation of the early hyperkalemia.
异丙肾上腺素和普萘洛尔单次给药后，无论是清醒大鼠还是麻醉犬，在15分钟和30分钟后都会引起高血糖。在后者这种动物中，未观察到血清钾的变化。静脉注射5微克/千克肾上腺素，在相同时间间隔引起高血糖，在第1分钟和第2分钟引起高钾血症，随后直至90分钟出现低钾血症。在肾上腺素给药前静脉注射5毫克/千克β-肾上腺素能阻滞剂索他洛尔，可抑制血糖升高和血清钾后期降低，但不能抑制早期高钾血症。在犬的离体后肢中，股动脉内注射3微克/千克肾上腺素，从15分钟开始，动脉或股静脉均出现类似的高血糖。相反，在第1分钟时，静脉中的血清钾浓度明显低于动脉。这些发现表明，肾上腺素对葡萄糖和钾的反应涉及不同的受体，并且骨骼肌在早期高钾血症的调节中起重要作用。
