Lu G, Zheng Z, Zhang L
Xiangya Hospital of Hunan Medical University, Changsha.
Zhonghua Liu Xing Bing Xue Za Zhi. 1998 Feb;19(1):27-9.
To evaluate the clinical effects of milrinone in patients with severe heart failure, heart function and clinical observations were performed on 25 patients with severe congestive heart failure treated with domestic intravenous milrinone for 15 days. Results showed that the total response rate to milrinone was 96% while 60% of them had significant improvement. Heart function and diameter of left atrial, left ventricle, and right ventricle were measured by pulsed Doppler and M-mode echocardiographg before and after the treatment. The systolic function of the left ventricle (such as SV, CO, EF, FS, IVST, PLVWT) was significantly improved. The diastolic function of the left ventricle (such as E peak, A peak, IRT) was also improved. Diameter of left atrial, left ventricle, and right ventricle was significantly reduced. The heart rate and blood pressure remained unchanged. No obvious side-effect was found in our observation. The domestic intravenous milrinone is a drug of choice for the management of patients with severe congestive heart failure.
为评估米力农对重度心力衰竭患者的临床疗效，对25例接受国产静脉注射米力农治疗15天的重度充血性心力衰竭患者进行了心功能及临床观察。结果显示，米力农的总有效率为96%，其中60%有显著改善。治疗前后采用脉冲多普勒和M型超声心动图测量心功能及左心房、左心室和右心室直径。左心室收缩功能（如每搏输出量、心输出量、射血分数、短轴缩短率、室间隔厚度、左心室后壁厚度）显著改善。左心室舒张功能（如E峰、A峰、等容舒张时间）也得到改善。左心房、左心室和右心室直径显著减小。心率和血压保持不变。在我们的观察中未发现明显副作用。国产静脉注射米力农是治疗重度充血性心力衰竭患者的首选药物。
