Zhu X, Lu G, Ou S
Beijing General Hospital, Ministry of Water Conservancys.
Zhonghua Liu Xing Bing Xue Za Zhi. 1998 Feb;19(1):30-2.
To evaluate the effects of plendia on oxygen free radicals and insulin resistance in patients with essential hypertension, thirty non-obesive moderate hypertensive patients were treated with plendil for 30 days. Antihypertensive effect and effects on serum lipid peroxide (LPO), superoxide dismutase (SOD), insulin sensitivity index (ISI) were studied. Results showed: 1. SOD activity and ISI decreased but contents of LPO and insulin increased in the treatment group. After a course of plendil therapy the above mentioned parameters fell to normal ranges. 2. Plendil had obvious antihypertensive effect but with no significant changes in heart rate. 3. Plendil had no significant effect on fasting blood glucose and lipids. Plendia was an effective and safe drug for treatment of essential hypertension. It also had the effects of antioxidation which improved the sensitivity to insulin.
为评估波依定对原发性高血压患者氧自由基及胰岛素抵抗的影响，对30例非肥胖型中度高血压患者给予波依定治疗30天。研究了其降压效果以及对血清脂质过氧化物（LPO）、超氧化物歧化酶（SOD）、胰岛素敏感指数（ISI）的影响。结果显示：1. 治疗组SOD活性及ISI降低，而LPO及胰岛素含量升高。经过一个疗程的波依定治疗后，上述参数降至正常范围。2. 波依定有明显的降压作用，但心率无显著变化。3. 波依定对空腹血糖和血脂无显著影响。波依定是治疗原发性高血压的一种有效且安全的药物。它还具有抗氧化作用，可提高胰岛素敏感性。
