Wang C, Li D
Sanitation and Anti-epidemic Station of Henan Province, Zhengzhou.
Zhonghua Liu Xing Bing Xue Za Zhi. 1998 Feb;19(1):43-6.
In order to identify the effect of hepatitis B vaccine in a vaccinated population, 5890 persons from 1890 families in 13 counties/cities in Henan province were chosen for investigation under multistage cluster systematic sampling. All subjects were bled for HBsAg, anti-HBs and anti-HBc by RIA. The positive rate of HBsAg was significantly lower in vaccinates than in that non-vaccinates. There was no protective effect in those who only vaccinated for one dose. It was preferable to receive vaccination before the age of two years. If 70% of hepatitis B vaccine coverage was reached among those younger than 5 years old, the positive rate of HBsAg could reduce to 1% or even lower. Results showed that it was important to ensure an earlier and full course vaccination with high coverage.
为确定乙肝疫苗在接种人群中的效果，采用多阶段整群系统抽样方法，对河南省13个县/市1890个家庭的5890人进行了调查。所有研究对象均采用放射免疫分析法检测HBsAg、抗-HBs和抗-HBc。接种组HBsAg阳性率显著低于未接种组。仅接种一剂者无保护作用。最好在两岁前接种疫苗。5岁以下儿童乙肝疫苗接种率若达到70%，HBsAg阳性率可降至1%甚至更低。结果表明，确保早期全程接种且接种率高非常重要。
