Zhang L, Ma J, Pan K
Beijing Cancer Institute and School of Oncology, Beijing Medical University.
Zhonghua Yu Fang Yi Xue Za Zhi. 1998 Mar;32(2):67-9.
To explore the difference in infection of Helicobacter pylori (Hp) and their subtypes cagA+ and hspA+ in the residents living in the areas with high and low incidence of gastric cancer.
Immunoglobulin G and A antibodies against Hp and immunoglobulin G antibodies against cagA+ and hspA+ were detected for the residents in Linqu and Cangshan Counties of Shandong Province with enzyme-linked immunosorbent assay (ELISA).
Rate of infection with Hp in the residents in Linqu County, an area with high incidence of gastric cancer, was 73.8 percent, significantly higher than that in Cangshan County (59.9%), an area with low incidence. Rates of infection with Hp cagA+ and hspA+ in the residents in Linqu County were 50.9 and 17.0 percent, respectively, also significantly higher than those in Cangshan County (34.0% and 13.2%, respectively). Sensitivities and specificities of the methods for detecting antibodies against Hp, cagA+ and hspA+ were 92.3, 63.2 and 21.9 percent and 71.0, 80.6 and 95.2 percent, respectively, evaluated with 13C-urea breath teat (13C-UBT). Rate of infection with Hp, especially with Hp cagA+, correlated significantly with the high incidence of gastric cancer.
The methods for detecting antibodies against Hp and cagA+ subtype are more sensitive and can be used as better indicators in epidemiological studies on gastric cancer.
探讨胃癌高、低发区居民幽门螺杆菌（Hp）及其cagA+和hspA+亚型感染情况的差异。
采用酶联免疫吸附试验（ELISA）检测山东省临朐县和苍山县居民抗Hp免疫球蛋白G和A抗体以及抗cagA+和hspA+免疫球蛋白G抗体。
胃癌高发区临朐县居民Hp感染率为73.8%，显著高于低发区苍山县居民（59.9%）。临朐县居民Hp cagA+和hspA+感染率分别为50.9%和17.0%，也显著高于苍山县居民（分别为34.0%和13.2%）。以13C尿素呼气试验（13C-UBT）为参照，检测抗Hp、cagA+和hspA+抗体方法的敏感度分别为92.3%、63.2%和21.9%，特异度分别为71.0%、80.6%和95.2%。Hp尤其是Hp cagA+感染率与胃癌高发显著相关。
检测抗Hp和cagA+亚型抗体的方法敏感度较高，可作为胃癌流行病学研究的较好指标。
