向大鼠延髓头端腹外侧注射莫索尼定对血压、心率及肾交感神经活动的影响。
Effects of moxonidine injected into rostral ventrolateral medulla on blood pressure, heart rate, and renal sympathetic nerve activity in rats.
作者信息
Xu Y F, He R R
机构信息
Department of Physiology, Hebei Medical University, Shijiazhuang, China.
出版信息
Zhongguo Yao Li Xue Bao. 1997 Sep;18(5):415-8.
AIM
To examine the effects of moxonidine (Mox) injected into the rostral ventrolateral medulla (RVLM) on blood pressure (BP), heart rate (HR), and the renal sympathetic nerve activity (RSNA) in anesthetized normotensive rats.
METHODS
BP, HR, and RSNA were simultaneously recorded after 1 microL Mox 1, 10, and 100 mumol.L-1 was injected into RVLM.
RESULTS
Mox 1, 10, and 100 mumol.L-1 reduced BP from 13.9 +/- 1.0 kPa to 13.0 +/- 1.7 kPa (P < 0.05), 13.8 +/- 1.8 kPa to 11.4 +/- 1.5 kPa (P < 0.01), and 13.9 +/- 1.9 kPa to 9.4 +/- 1.7 kPa (P < 0.01), respectively. Mox did not influence HR. RSNA varied with the doses: Mox 1 mumol.L-1 increased RSNA by 50% (P < 0.05), 10 mumol.L-1 insignificantly influenced RSNA (P > 0.05), and 100 mumol.L-1 reduced RSNA by 23% (P < 0.05). In sinoaortic barodenervated rats, Mox 10 mumol.L-1 inhibited RSNA by 50% (P < 0.05), which substantially differed from that in buffer nerve intact rats (P < 0.01).
CONCLUSION
Mox injected into RVLM decreased BP, but did not influence HR. The changes of RSNA did not parallel with the depressor effect of Mox.
目的
研究向延髓头端腹外侧区（RVLM）注射莫索尼定（Mox）对麻醉的正常血压大鼠的血压（BP）、心率（HR）和肾交感神经活动（RSNA）的影响。
方法
向RVLM注射1微升1、10和100微摩尔·升⁻¹的Mox后，同时记录BP、HR和RSNA。
结果
1、10和100微摩尔·升⁻¹的Mox分别使BP从13.9±1.0千帕降至13.0±1.7千帕（P<0.05）、从13.8±1.8千帕降至11.4±1.5千帕（P<0.01）、从13.9±1.9千帕降至9.4±1.7千帕（P<0.01）。Mox不影响HR。RSNA随剂量变化：1微摩尔·升⁻¹的Mox使RSNA增加50%（P<0.05），10微摩尔·升⁻¹对RSNA无显著影响（P>0.05），100微摩尔·升⁻¹使RSNA降低23%（P<0.05）。在去窦主动脉神经大鼠中，10微摩尔·升⁻¹的Mox使RSNA抑制50%（P<0.05），这与缓冲神经完整的大鼠有显著差异（P<0.01）。
结论
向RVLM注射Mox可降低BP，但不影响HR。RSNA的变化与Mox的降压作用不平行。
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