马钱子碱对小鼠非特异性免疫反应的影响。
Effect of brucine on mouse nonspecific immune responses.
作者信息
Zhao H W, Li Y H, Zhu Y N, Weng S A, Zhang Y, Ge S W
机构信息
Department of Pharmacology, Henan Medical University, Zhengzhou, China.
出版信息
Zhongguo Yao Li Xue Bao. 1997 Sep;18(5):468-70.
AIM
To evaluate the effect of brucine (Bru) i.p. at analgesic doses on the nonspecific immune responses in normal and cyclophosphamide (Cyc)-treated mice.
METHODS
The clearance of charcoal particles, the immune organ weights, the white blood cell counts in peripheral blood, the phagocytosis to neutral red (NR) of PMO and its IL-1 production in vitro were tested.
RESULTS
In normal mice, Bru slightly enhanced the clearance of charcoal particles, the phagocytosis of PMO, IL-1 production, the immune organ weights and the WBC counts (P > 0.05), whereas in Cyc-induced subnormal immunity model mice, Bru greatly enhanced these nonspecific immune responses (P < 0.05 or P < 0.01). The effects of Bru were most marked i.p. at 10 mg.kg-1 in vivo or 0.1-10 mg.L-1 in vitro.
CONCLUSION
Bru i.p. at an analgesic dosage has dose- and function-dependent immunoregulatory effects.
目的
评估镇痛剂量的马钱子碱（Bru）腹腔注射对正常小鼠和环磷酰胺（Cyc）处理小鼠非特异性免疫反应的影响。
方法
检测炭粒廓清率、免疫器官重量、外周血白细胞计数、腹腔巨噬细胞对中性红（NR）的吞噬作用及其体外白细胞介素-1的产生。
结果
在正常小鼠中，马钱子碱略微增强了炭粒廓清率、腹腔巨噬细胞的吞噬作用、白细胞介素-1的产生、免疫器官重量和白细胞计数（P>0.05），而在环磷酰胺诱导的免疫低下模型小鼠中，马钱子碱显著增强了这些非特异性免疫反应（P<0.05或P<0.01）。马钱子碱腹腔注射的作用在体内10mg.kg-1或体外0.1-10mg.L-1时最为显著。
结论
镇痛剂量的马钱子碱腹腔注射具有剂量和功能依赖性的免疫调节作用。
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