Wang G Y, Lin Z B
Department of Pharmacology, School of Basic Medical Sciences, Beijing Medical University, China.
Zhongguo Yao Li Xue Bao. 1997 Mar;18(2):180-2.
To study the effect of 10-hydroxy-2-decenoic acid (HDA) on the macrophages activity of rats in vitro.
To measure the effects of HDA on phagocytosis, the production of antitumor cytokines tumor necrosis factor (TNF) and interleukin-1 (IL-1) in vitro.
HDA 50, 100 mg.L-1 promoted phagocytic activity from 0.353 +/- 0.017 to 0.39 +/- 0.04 and 0.382 +/- 0.017 A, increased TNF and IL-1 production from 0.23 +/- 0.07% to 0.43 +/- 0.04%, 0.47 +/- 0.04% and from 2384 +/- 180 to 2943 +/- 295, 3825 +/- 450 dpm, respectively.
The upregulating effects of HDA on phagocytosis of PMO and production of TNF, IL-1 contribute to the host antitumor and immunomodulating mechanism.
研究10-羟基-2-癸烯酸（HDA）对大鼠巨噬细胞体外活性的影响。
检测HDA对体外吞噬作用、抗肿瘤细胞因子肿瘤坏死因子（TNF）和白细胞介素-1（IL-1）产生的影响。
50、100mg.L-1的HDA将吞噬活性从0.353±0.017提高至0.39±0.04和0.382±0.017A，使TNF和IL-1的产生分别从0.23±0.07%增至0.43±0.04%、0.47±0.04%，以及从2384±180增至2943±295、3825±450dpm。
HDA对巨噬细胞吞噬作用及TNF、IL-1产生的上调作用有助于宿主的抗肿瘤和免疫调节机制。
