10-羟基-2-癸烯酸对体外培养的腹膜巨噬细胞吞噬作用及细胞因子产生的影响。
Effects of 10-hydroxy-2-decenoic acid on phagocytosis and cytokines production of peritoneal macrophages in vitro.
作者信息
Wang G Y, Lin Z B
机构信息
Department of Pharmacology, School of Basic Medical Sciences, Beijing Medical University, China.
出版信息
Zhongguo Yao Li Xue Bao. 1997 Mar;18(2):180-2.
AIM
To study the effect of 10-hydroxy-2-decenoic acid (HDA) on the macrophages activity of rats in vitro.
METHODS
To measure the effects of HDA on phagocytosis, the production of antitumor cytokines tumor necrosis factor (TNF) and interleukin-1 (IL-1) in vitro.
RESULTS
HDA 50, 100 mg.L-1 promoted phagocytic activity from 0.353 +/- 0.017 to 0.39 +/- 0.04 and 0.382 +/- 0.017 A, increased TNF and IL-1 production from 0.23 +/- 0.07% to 0.43 +/- 0.04%, 0.47 +/- 0.04% and from 2384 +/- 180 to 2943 +/- 295, 3825 +/- 450 dpm, respectively.
CONCLUSION
The upregulating effects of HDA on phagocytosis of PMO and production of TNF, IL-1 contribute to the host antitumor and immunomodulating mechanism.
目的
研究10-羟基-2-癸烯酸（HDA）对大鼠巨噬细胞体外活性的影响。
方法
检测HDA对体外吞噬作用、抗肿瘤细胞因子肿瘤坏死因子（TNF）和白细胞介素-1（IL-1）产生的影响。
结果
50、100mg.L-1的HDA将吞噬活性从0.353±0.017提高至0.39±0.04和0.382±0.017A，使TNF和IL-1的产生分别从0.23±0.07%增至0.43±0.04%、0.47±0.04%，以及从2384±180增至2943±295、3825±450dpm。
结论
HDA对巨噬细胞吞噬作用及TNF、IL-1产生的上调作用有助于宿主的抗肿瘤和免疫调节机制。
Zotero 插件