Ruan H Z, Li X C, Li H D, Zhao B Y
Department of Physiology, Third Military Medical College, Chongqing, China.
Zhongguo Yao Li Xue Bao. 1997 Sep;18(5):474-6.
To observer the effect of intrathecal injection of somatostatin (Som) associated with electroacupuncture (EA) at "Jiaji" points on c-fos protein expression of spinal cord in pain rats.
Rats with adjuvant arthritis were used as pain model and the c-fos-like immunoreactivity (FLI) was detected by immunohistochemistry.
The c-fos protein expression induced by arthritis were found in all of the I-X laminae of ipsilateral spinal cord of rats, and most of the labeled cells were located in the laminae I-II and V-VI. Som and EA suppressed the c-fos expression and the lessening of FLI cells in the spinal cord.
Pathological pain following arthritis activated pain sensitive neurons (PSN) and evoked c-fos expression in spinal cord, Som and EA suppressed activities of these PSN, producing the effect of analgesia.
观察鞘内注射生长抑素（Som）联合电针“夹脊”穴对疼痛大鼠脊髓c-fos蛋白表达的影响。
采用佐剂性关节炎大鼠作为疼痛模型，通过免疫组织化学检测c-fos样免疫反应性（FLI）。
在大鼠同侧脊髓的Ⅰ-Ⅹ层均发现了由关节炎诱导的c-fos蛋白表达，大多数标记细胞位于Ⅰ-Ⅱ层和Ⅴ-Ⅵ层。生长抑素和电针抑制了脊髓中c-fos的表达及FLI细胞的减少。
关节炎后的病理性疼痛激活了痛觉敏感神经元（PSN）并诱发脊髓中c-fos表达，生长抑素和电针抑制了这些PSN的活动，产生镇痛作用。
