[超氧化物歧化酶对创伤小鼠淋巴细胞膜流动性及功能的影响]

[Effect of superoxide dismutase on membrane fluidity and functions of lymphocytes in traumatized mice].

作者信息

Luo Y, Liang H, Wang Z, Geng B, Xu X

机构信息

Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing.

出版信息

Zhongguo Ying Yong Sheng Li Xue Za Zhi. 1997 Nov;13(4):309-11.

PMID:10322956

Abstract

Effect of superoxide dismutase (SOD) on membrane fluidity and functions of lymphocytes in traumatized mice was studied. The results showed that in vivo administration of SOD (10,000 U/kg.d, from 0 to 3 days posttrauma) could significantly decrease malondialdehyde (MDA) contents in serum, lymphatic tissues from spleen, thymus, mesenteric lymph nodes and T cells plasmalemma, mitochondria, microsome, restore decreased T lymphocytes and T cells in traumatized mice, elevate membrane fluidity of lymphocytes transformation (TLT), reduce interleukin 2 (IL-2) production, supprssed IL-2 receptor (IL-2R) expression and depress IL-2 mediated lymphocyte proliferation response (IL 2MLPR) after trauma in various degress. It is suggested that SOD may protect lymphocytes post trauma from damage of oxygen free radical, and elevate lymphocytes functions.

摘要

研究了超氧化物歧化酶（SOD）对创伤小鼠淋巴细胞膜流动性及功能的影响。结果表明，创伤后0至3天内，体内给予SOD（10,000 U/kg.d）可显著降低血清、脾脏、胸腺、肠系膜淋巴结等淋巴组织以及T细胞膜、线粒体、微粒体中的丙二醛（MDA）含量，使创伤小鼠体内减少的T淋巴细胞及T细胞得以恢复，不同程度地提高淋巴细胞转化膜流动性（TLT），减少白细胞介素2（IL-2）的产生，抑制IL-2受体（IL-2R）的表达，并抑制创伤后IL-2介导的淋巴细胞增殖反应（IL 2MLPR）。提示SOD可能保护创伤后淋巴细胞免受氧自由基损伤，并提高淋巴细胞功能。