[神经肽Y微离子透入对孤束核中对压力和化学感受器有反应的神经元的影响]

[Effects of NPY microionophoresis on the units in nucleus tractus solitarius (NTS) responsive to baro- and chemoreceptor].

作者信息

Zhao H, Wang L, Hua S, Wang S

机构信息

Department of Physiology, Norman Bethune University of Medical Sciences.

出版信息

Zhongguo Ying Yong Sheng Li Xue Za Zhi. 1997 Nov;13(4):333-6.

PMID:10322964

Abstract

This experiment is designed to study the effects of NPY microionophoresis on the units in NTS responsive to baro- and chemoreceptor activiation at cellular level. In the experiment, it examined 62 units with spontaneous discharge in NTS. Among them, 34 were excited and 19 were inhibited by NPY microionophoresis. And other 9 units failed to respond to NPY microionophoresis. The units with the increase and decrease of discharge frequency to the activation of carotid baroreceptor showed excitation (16/21) and inhibition (7/11) respectively in response to NPY microionophoresis. The units with the increase (8/14) and decrease (5/9) of discharge frequency to the activation of carotid chemoreceptor mainly showed excitation.

摘要

本实验旨在从细胞水平研究神经肽Y（NPY）微电泳对孤束核（NTS）中对压力和化学感受器激活有反应的神经元的影响。实验中，对NTS中62个有自发放电的神经元进行了检测。其中，34个神经元被NPY微电泳兴奋，19个被抑制。另外9个神经元对NPY微电泳无反应。对颈动脉压力感受器激活时放电频率增加和减少的神经元，对NPY微电泳的反应分别表现为兴奋（16/21）和抑制（7/11）。对颈动脉化学感受器激活时放电频率增加（8/14）和减少（5/9）的神经元主要表现为兴奋。