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[先天性心脏异常与心脏功能障碍:产前诊断如何改变生存几率]

[Congenital heart abnormalities and cardiac dysfunction: how prenatal diagnosis changed the chances for survival].

作者信息

Hajdú J, Marton T, Tóth P E, Papp C, Oroszné N J, Mogyorósi G, Papp Z

机构信息

Semmelweis Orvostudományi Egyetem, Budapest.

出版信息

Orv Hetil. 1999 Apr 11;140(15):815-8.

PMID:10323073
Abstract

Because of the rapid development of sonography, there are many new informations on embryonal and fetal circulation and pathophysiology of decompensation. Echocardiography is a useful tool to follow intrauterine therapy. Authors have examined the effect of prenatal diagnosis on the prevalence of heart abnormalities, terms of cardiac surgery, perinatal mortality and mortality due to heart abnormalities or decompensation. During five years they have found 187 severe heart abnormalities. Because of parental request 90 pregnancies have been terminated. Following prenatal diagnosis in 16 cases planned surgery of the newborn, in 14 cases planned cesarean sections have been done. From 64 transplacentar treatments 44 patients have survived. Authors have found, that prenatal diagnosis had good effect on short term survival rate but had no effect on long term survival rate. Fetal echocardiography has selective and therapeutic effect. The selective effect depends on second trimester screening. The therapeutic effect was significant in cases of arrhythmias and decompensation.

摘要

由于超声检查技术的迅速发展,关于胚胎和胎儿循环以及失代偿病理生理学有了许多新信息。超声心动图是跟踪宫内治疗的有用工具。作者研究了产前诊断对心脏异常患病率、心脏手术时机、围产期死亡率以及因心脏异常或失代偿导致的死亡率的影响。在五年期间,他们发现了187例严重心脏异常。由于父母的要求,90例妊娠被终止。在产前诊断后,16例计划对新生儿进行手术,14例进行了剖宫产。64例经胎盘治疗的患者中有44例存活。作者发现,产前诊断对短期存活率有良好影响,但对长期存活率没有影响。胎儿超声心动图具有选择和治疗作用。选择作用取决于孕中期筛查。治疗作用在心律失常和失代偿病例中显著。

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