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UDP-glucuronosyltransferase inhibitors.

作者信息

Golovinsky E, Naydenova Z, Grancharov K

机构信息

Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia.

出版信息

Eur J Drug Metab Pharmacokinet. 1998 Oct-Dec;23(4):453-6. doi: 10.1007/BF03189994.

DOI:10.1007/BF03189994
PMID:10323326
Abstract
摘要

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本文引用的文献

1
Inhibition of UDP-glucuronyltransferase activity in rat liver microsomes by pyrimidine derivatives.
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1995 Nov;112(3):321-5. doi: 10.1016/0742-8413(95)02027-6.
2
Synthesis and characterization of a new class of inhibitors of membrane-associated UDP-glycosyltransferases.
J Biol Chem. 1993 Jun 15;268(17):12933-8.
3
The expression of UDP-glucuronosyltransferases of the UGT1 family in human liver and kidney and in response to drugs.UGT1家族的尿苷二磷酸葡萄糖醛酸转移酶在人肝脏和肾脏中的表达以及对药物的反应。
Biochem Pharmacol. 1993 Jan 26;45(2):295-301. doi: 10.1016/0006-2952(93)90064-4.
4
A recombinant phenobarbital-inducible rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 2B1) stably expressed in V79 cells catalyzes the glucuronidation of morphine, phenols, and carboxylic acids.一种在V79细胞中稳定表达的重组苯巴比妥诱导型大鼠肝脏UDP-葡萄糖醛酸基转移酶（UDP-葡萄糖醛酸基转移酶2B1）催化吗啡、酚类和羧酸的葡萄糖醛酸化反应。
Mol Pharmacol. 1994 Jan;45(1):42-50.
5
Photoaffinity labeling for evaluation of uridinyl analogs as specific inhibitors of rat liver microsomal UDP-glucuronosyltransferases.用于评估尿苷类似物作为大鼠肝脏微粒体UDP-葡萄糖醛酸转移酶特异性抑制剂的光亲和标记法。
Biochim Biophys Acta. 1994 Apr 13;1205(2):336-45. doi: 10.1016/0167-4838(94)90253-4.
6
Chemical modification of human UDP-glucuronosyltransferase UGT1*6 by diethyl pyrocarbonate: possible involvement of a histidine residue in the catalytic process.焦碳酸二乙酯对人尿苷二磷酸葡萄糖醛酸基转移酶UGT1*6的化学修饰：催化过程中组氨酸残基的可能作用。
Arch Biochem Biophys. 1994 Mar;309(2):266-72. doi: 10.1006/abbi.1994.1112.
7
Modulation of benzo[a]pyrene bioactivation by glucuronidation in lymphocytes and hepatic microsomes from rats with a hereditary deficiency in bilirubin UDP-glucuronosyltransferase.胆红素UDP-葡萄糖醛酸基转移酶遗传性缺乏大鼠淋巴细胞和肝微粒体中葡萄糖醛酸化对苯并[a]芘生物活化的调节作用。
Toxicol Appl Pharmacol. 1994 Aug;127(2):306-13. doi: 10.1006/taap.1994.1166.
8
The chemical modification of human liver UDP-glucuronosyltransferase UGT1*6 reveals the involvement of a carboxyl group in catalysis.
FEBS Lett. 1994 Jun 13;346(2-3):146-50. doi: 10.1016/0014-5793(94)00453-6.
9
Heterogeneity of hepatic UDP-glucuronosyltransferase activities: investigations of isoenzymes involved in p-nitrophenol glucuronidation.肝脏UDP-葡萄糖醛酸基转移酶活性的异质性：对参与对硝基苯酚葡萄糖醛酸化的同工酶的研究。
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993 Sep;106(1):241-8. doi: 10.1016/0742-8413(93)90278-s.
10
Potential genoprotective role for UDP-glucuronosyltransferases in chemical carcinogenesis: initiation of micronuclei by benzo(a)pyrene and benzo(e)pyrene in UDP-glucuronosyltransferase-deficient cultured rat skin fibroblasts.尿苷二磷酸葡萄糖醛酸转移酶在化学致癌作用中的潜在基因保护作用：苯并(a)芘和苯并(e)芘在尿苷二磷酸葡萄糖醛酸转移酶缺陷的培养大鼠皮肤成纤维细胞中引发微核。
Cancer Res. 1995 Mar 1;55(5):1045-51.