假性甲状旁腺功能减退症中的皮肤骨瘤。

Osteoma cutis in pseudohypoparathyroidism.

作者信息

Goeteyn V, De Potter C R, Naeyaert J M

机构信息

Department of Dermatology, University Hospital Gent, Belgium.

出版信息

Dermatology. 1999;198(2):209-11. doi: 10.1159/000018115.

DOI:10.1159/000018115

PMID:10325484

Abstract

Pseudohypoparathyroidism (PHP) is a hereditary disorder characterized by an end-organ resistance for parathormone. PHP can be classified into different types by biochemical and phenotypic characteristics and the level of the defect in the hormone-receptor complex. PHP is described as Albright's hereditary osteodystrophy (AHO) when a specific phenotype is present. We report a case of osteoma cutis in a 30-year-old woman with AHO. Successful treatment was obtained by debriding the lesion followed by split-thickness skin grafting.

摘要

假性甲状旁腺功能减退症（PHP）是一种遗传性疾病，其特征为终末器官对甲状旁腺激素产生抵抗。PHP可根据生化和表型特征以及激素受体复合物中的缺陷水平分为不同类型。当存在特定表型时，PHP被描述为奥尔布赖特遗传性骨营养不良（AHO）。我们报告一例30岁患有AHO的女性皮肤骨瘤病例。通过切除病变组织并随后进行中厚皮片移植获得了成功治疗。