在接受体外循环的兔中，用激光多普勒测速仪测量多内脏部位血流时多巴胺酚丁胺的作用。

Effects of dopexamine on blood flow in multiple splanchnic sites measured by laser Doppler velocimetry in rabbits undergoing cardiopulmonary bypass.

作者信息

Bastien O, Piriou V, Aouifi A, Evans R, Lehot J J

机构信息

Université Claude Bernard, Lyon, France.

出版信息

Br J Anaesth. 1999 Jan;82(1):104-9. doi: 10.1093/bja/82.1.104.

DOI:10.1093/bja/82.1.104

PMID:10325845

Abstract

Decreased gut perfusion has been reported during cardiopulmonary bypass (CPB). Studies of treatments to avoid splanchnic ischaemia during CPB have given conflicting results. We studied 12 rabbits during mild hypothermic non-pulsatile CPB. Tissue blood flow in three different splanchnic areas (gastric, jejunum and ileum) was measured by laser Doppler velocimetry (LDV) before CPB (T0), after steady state (T1), after administration of dopexamine 2 micrograms kg-1 min-1 (T2) and 4 micrograms kg-1 min-1 (T3), and after return to baseline (T4). Splanchnic blood flow decreased during CPB. Dopexamine increased significantly jejunum LDV (100% at T1 to mean 271 (SD 210)% at T2) and ileum LDV (100% at T1 to 187 (112)% at T2). Gastric LDV was not altered by infusion of dopexamine during CPB. This could partly explain the conflicting results on the value of gastric tonometry as an index of splanchnic injury.

摘要

据报道，在体外循环（CPB）期间肠道灌注会减少。关于在CPB期间避免内脏缺血的治疗方法的研究结果相互矛盾。我们对12只兔子进行了轻度低温非搏动性CPB研究。在CPB前（T0）、稳态后（T1）、给予多培沙明2微克/千克/分钟（T2）和4微克/千克/分钟（T3）后以及恢复到基线后（T4），通过激光多普勒测速仪（LDV）测量三个不同内脏区域（胃、空肠和回肠）的组织血流。CPB期间内脏血流减少。多培沙明显著增加了空肠LDV（T1时为100%，T2时平均为271（标准差210）%）和回肠LDV（T1时为100%，T2时为187（112）%）。CPB期间输注多培沙明未改变胃LDV。这可能部分解释了胃张力测定作为内脏损伤指标的价值方面相互矛盾的结果。