Stoel L J, Newman E C, Asleson G L, Frank C W
J Pharm Sci. 1976 Dec;65(12):1794-9. doi: 10.1002/jps.2600651225.
The interaction of various metal ions with anhydrotetracycline was investigated. A comparison of the UV-visible and fluorescence spectral characteristics of anhydrotetracycline and its metal-ion complexes with a number of modified anhydrotetracyclines in the presence of metal ions suggested that the C-11 oxygen was involved in metal-ion binding. Secondary binding was observed in the A-ring by circular dichroism when the primary site was blocked.
研究了各种金属离子与脱水四环素的相互作用。对脱水四环素及其金属离子络合物与多种修饰的脱水四环素在金属离子存在下的紫外可见光谱和荧光光谱特征进行比较，结果表明C-11位的氧参与了金属离子的结合。当主要结合位点被阻断时，通过圆二色性观察到A环中的二级结合。
