Khan K A, Rhodes C T
J Pharm Sci. 1976 Dec;65(12):1835-7. doi: 10.1002/jps.2600651235.
The effect of variation in compaction force on six direct compression tablet matrixes was investigated. An instrumented tablet press allowed direct measurement of applied and ejection forces. Hardness, apparent tablet density, and disintegration times also were determined. The disintegration time of spray-dried lactose tablets was essentially independent of compaction force. However, in the other systems investigated, the properties studied showed varying types of dependence on compaction pressure. A direct compression formula was developed and exhibits a decrease in disintegration time as compaction force is increased.
研究了压实力变化对六种直接压片基质的影响。一台装有仪器的压片机可直接测量施加力和顶出力。还测定了硬度、表观片剂密度和崩解时间。喷雾干燥乳糖片的崩解时间基本与压实力无关。然而，在所研究的其他体系中，所研究的性质对压实压力呈现出不同类型的依赖性。开发了一种直接压片配方，随着压实力的增加，崩解时间会缩短。
