Burkova T, Baĭnova A, Ivanova L
Probl Khig. 1976;2:45-50.
Not infrequently, the continuous use of pesticides leads to production of resistant species of agricultural pests which makes imperative to adopt the practice of intermittent, i. e. periodic application of the agricultural preparations. In this work the difference in degree of pathoanatomical damage upon chronic and periodic, weekly application of the new carbamide pesticide Pyrimor, extensively used in the Bulgarian farming economy, is discussed. The results of pathomorphological and histochemical study of the chief parenchymatous organs shows a clearcut difference in the group with continuous administration of the pesticide, as compared to the control and intermittently poisoned group. It is furthermore pointed out that the two-times higher dose, introduced at weekly intervals, leads to slighter lesions of parenchymatous organs in comparison with chronic, oral Pyrimor treatment. Season related, incessant use of pesticides results in occupational risk increase among the workers engaged in farming.
农药的持续使用常常会导致农业害虫产生抗性品种，这使得采用间歇性（即定期）施用农用制剂的做法成为必要。在这项工作中，讨论了长期和每周定期施用保加利亚农业经济中广泛使用的新型尿素农药抗蚜威后，病理解剖损伤程度的差异。对主要实质器官的病理形态学和组织化学研究结果表明，与对照组和间歇性中毒组相比，持续施用农药的组有明显差异。此外还指出，与长期口服抗蚜威治疗相比，每周间隔施用两倍剂量的农药会导致实质器官的损伤更轻。与季节相关的农药持续使用会增加从事农业工作的工人的职业风险。
