Genest D R, Di Salvo D, Rosenblatt M J, Holmes L B
Division of Women's Perinatal Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Clin Dysmorphol. 1999 Jan;8(1):53-8.
We report a fetus from an elective termination at 17 weeks gestation following maternal ingestion of 1200 micrograms of misoprostol at 7 weeks of gestation. The fetus had abscence of the middle and distal phalanges of fingers 1, 3, 4 and 5 with tethering by thin strands of tissue on one hand, a below-knee amputation of one leg and omphalocele. There was absence of amnion on the chorionic surface of the placenta, a pathologic feature of early amnion rupture. The association in this case of the phenotypic features of the amniotic band syndrome suggests that the teratogenicity of misoprostol at 9 to 12 weeks gestation can overlap that of other acute insults at that time, such as chorionic villus sampling, dilatation and curettage and abdominal trauma in the first trimester.
我们报告了一例妊娠17周时选择性终止妊娠的胎儿，其母亲在妊娠7周时摄入了1200微克米索前列醇。该胎儿1、3、4和5指中节和远节指骨缺如，一只手被细组织束牵拉，一条腿膝下截肢，并有脐膨出。胎盘绒毛膜表面无羊膜，这是早期羊膜破裂的病理特征。本例羊膜带综合征的表型特征提示，妊娠9至12周时米索前列醇的致畸性可能与当时的其他急性损伤（如绒毛取样、刮宫术和孕早期腹部创伤）的致畸性重叠。
