固醇调节元件结合蛋白：胆固醇和脂肪酸生物合成的激活剂。
Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis.
作者信息
Horton J D, Shimomura I
机构信息
Department of Molecular Genetics, University of Texas Southwestern Medical Centre, Dallas 75235, USA.
出版信息
Curr Opin Lipidol. 1999 Apr;10(2):143-50. doi: 10.1097/00041433-199904000-00008.
Abstract
A family of transcription factors designated sterol regulatory element-binding proteins (SREBPs) mediates the previously described end-product feedback regulation of cholesterol biosynthesis. In addition, SREBPs are emerging as important regulators of fatty acid synthesis. The current review focuses on the in-vivo regulation of SREBPs in liver and the coordinate regulation of SREBP-activated target genes.
摘要
一类被称为固醇调节元件结合蛋白（SREBPs）的转录因子介导了先前所述的胆固醇生物合成的终产物反馈调节。此外，SREBPs正逐渐成为脂肪酸合成的重要调节因子。本综述重点关注肝脏中SREBPs的体内调节以及SREBP激活的靶基因的协同调节。
Zotero 插件