Olivier C, Radal M, Mazaud S, Jonville-Béra A P, Martel C, Autret E
Service de pédiatrie générale, hôpital Louis-Mourier, Colombes, France.
Arch Pediatr. 1998 Mar;5(3):289-90. doi: 10.1016/s0929-693x(97)89371-2.
We report a rash after the first dose of antituberculosis polytherapy which raises questions concerning procedures to be followed.
An 8-year-old child presented with a pruritic rash 1.5 hours after the first dose of isoniazide, rifampicine, pyrazinamide and ethambutol was simultaneously administered, which did not recur after successive re-administration of isoniazide and rifampicine. Pyrazinamide, which was re-administered last, induced a recurrence. Slower pyrazinamide re-administration allowed continuation of treatment.
A protocol for re-administration of the four drugs is suggested.
我们报告了首例抗结核联合治疗后出现皮疹的病例，这引发了关于后续治疗程序的问题。
一名8岁儿童在首次同时服用异烟肼、利福平、吡嗪酰胺和乙胺丁醇1.5小时后出现瘙痒性皮疹，在后续再次服用异烟肼和利福平后未复发。最后重新服用的吡嗪酰胺导致皮疹复发。较慢地重新服用吡嗪酰胺使治疗得以继续。
建议制定四种药物重新给药的方案。
