Tang S, Parsons P J, Perl D
Wadsworth Center, New York State Department of Health, Albany 12201-0509, USA.
Biol Trace Elem Res. 1999 Jun;68(3):267-79. doi: 10.1007/BF02783908.
Longitudinal and lateral variations in Al concentration in several large animal (bovine and caprine) long bones (tibia and femur) and several human clavicle bones were examined using a sensitive analytical method based on electrothermal atomization atomic absorption spectrometry with Zeeman background correction. Bone segments were carefully removed using special tools free of significant Al contamination, freeze-dried, and digested overnight at room temperature in concentrated HNO3. Bone digestates were analyzed for Al using simple aqueous calibration standards with a Ca(NO3)2 modifier. Mean bone Al concentrations were relatively low (<1 microg/g, dry weight) in bovine and caprine long bones compared to literature values for human bone samples. Longitudinal variations of Al in the animal bones examined appeared relatively uniform compared to the human clavicle bones, where, in three of five cases, Al appeared enriched at the epiphyses (joints). The Al "enrichment" was symmetrical with respect to both left and right clavicle bones. Aluminum concentrations at the mid-shaft of the clavicle bone show less variation compared to whole bone studies, but considerable scatter is evident along the bone length. The mean bone aluminum concentration in the five human subjects varied from 1 to 6 microg/g dry weight.
使用基于带塞曼背景校正的电热原子吸收光谱法的灵敏分析方法，对几种大型动物（牛和羊）的长骨（胫骨和股骨）以及几块人类锁骨中的铝浓度的纵向和横向变化进行了检测。使用无明显铝污染的特殊工具小心地取出骨段，冷冻干燥，并在室温下于浓硝酸中消化过夜。使用含Ca(NO3)2改性剂的简单水溶液校准标准品分析骨消化液中的铝。与人类骨样品的文献值相比，牛和羊长骨中的平均骨铝浓度相对较低（<1微克/克，干重）。与人类锁骨相比，所检测的动物骨中铝的纵向变化显得相对均匀，在五例中的三例中，人类锁骨的骨骺（关节处）铝含量较高。铝的“富集”在左右锁骨上是对称的。与全骨研究相比，锁骨骨干中部的铝浓度变化较小，但沿骨长有明显的离散。五名人类受试者的平均骨铝浓度在1至6微克/克干重之间变化。
