Lee H, Tarazi F I, Chakos M, Wu H, Redmond M, Alvir J M, Kinon B J, Bilder R, Creese I, Lieberman J A
Hillside Hospital, Division of Long Island Jewish Hospital, New York, NY 11004, USA.
Life Sci. 1999;64(18):1595-602. doi: 10.1016/s0024-3205(99)00106-x.
Human MRI studies have demonstrated that treatment with typical antipsychotics may increase the volume of the caudate nucleus while clozapine treatment is associated with either no change or a reversal of the previous volume increase. In this study four groups of seven rats were treated for 8 months with either the typical antipsychotic haloperidol, the atypical antipsychotic clozapine, the D2/D3 receptor antagonist raclopride, or vehicle (plain drinking water). Striatal sections were prepared using D1-like and D2-like receptor ligand autoradiography. Images (4-6 sections per rat, per ligand) were digitized and the area of the striatum was measured on each section. Rats treated with haloperidol did not have a larger mean striatum area than the control group on either D1- or D2-like ligand autoradiograms. Using the D2-like ligand autoradiograms, the clozapine treated animals had a smaller mean striatum area than the control group. Mean left striatum area was larger than mean right striatum area in each treatment group and in the control group. In contrast to the MRI findings reported in schizophrenia, the area of the striatum was not increased in rats treated with typical antipsychotic agents, but the clozapine-associated area reduction may parallel the clinical studies.
人类磁共振成像研究表明，使用典型抗精神病药物治疗可能会增加尾状核的体积，而氯氮平治疗则与体积无变化或先前增加的体积逆转有关。在本研究中，将四组每组七只大鼠用典型抗精神病药物氟哌啶醇、非典型抗精神病药物氯氮平、D2/D3受体拮抗剂雷氯必利或赋形剂（普通饮用水）治疗8个月。使用D1样和D2样受体配体放射自显影术制备纹状体切片。对图像（每只大鼠、每个配体4 - 6个切片）进行数字化处理，并测量每个切片上纹状体的面积。在D1样或D2样配体放射自显影图上，用氟哌啶醇治疗的大鼠的平均纹状体面积并不比对照组大。使用D2样配体放射自显影图，氯氮平治疗的动物的平均纹状体面积比对照组小。在每个治疗组和对照组中，左侧纹状体的平均面积大于右侧纹状体的平均面积。与精神分裂症中报道的磁共振成像结果相反，用典型抗精神病药物治疗的大鼠纹状体面积并未增加，但氯氮平相关的面积减少可能与临床研究结果相似。
