Snowden J A, Brooks P M
Department of Haematology, Royal Hallamshire Hospital, Sheffield, United Kingdom.
Curr Opin Rheumatol. 1999 May;11(3):167-72. doi: 10.1097/00002281-199905000-00003.
The concept of using hematopoietic stem cell transplantation to treat patients with autoimmune disease was first provided by animal studies and anecdotal case reports. Advances over recent years in autologous hematopoietic stem cell transplantation, most notably cytokine-mobilized peripheral blood stem cells, have been followed by its specific use to treat severe autoimmune and inflammatory diseases. Guidelines have been published, and, by March 1999, 150 cases were registered with the International Autoimmune Disease Stem Cell Project Database. This review summarizes the literature published with respect to inflammatory rheumatic disease over the past few years and discusses future directions aimed at refining this intensive approach.
利用造血干细胞移植治疗自身免疫性疾病患者的概念最初源于动物研究和个别病例报告。近年来，自体造血干细胞移植取得了进展，最显著的是细胞因子动员的外周血干细胞，随后其被专门用于治疗严重的自身免疫性和炎性疾病。相关指南已发布，截至1999年3月，国际自身免疫性疾病干细胞项目数据库已登记了150例病例。本综述总结了过去几年发表的关于炎性风湿性疾病的文献，并讨论了旨在完善这种强化治疗方法的未来方向。
