Bureau F, Uystepruyst C H, Coghe J, Van de weerdt M, Lekeux P
Laboratory for Functional Investigation, Department of Physiology, University of Liège, Liège, Belgium.
Vet J. 1999 May;157(3):302-8. doi: 10.1053/tvjl.1998.9999.
The purposes of the present study were: (1) to develop original equations to predict spirometric variables (SV) in healthy Friesian and Belgian White and Blue (BWB) calves < 1 year of age; and (2) to determine the effects of somatic growth on SV. Sixty-seven Friesian and 500 BWB calves were investigated. For each calf, the following SV were calculated: (1) the average minute volume derived using all the ventilatory cycles recorded during the 15 s of maximal ventilatory changes induced by lobeline administration (0.25 mg/kg, i.v.) (15-s LMV); (2) the maximal tidal volume, the maximal peak expiratory flow and the maximal peak inspiratory flow recorded from single breaths after lobeline administration (MVTL, MPEFLand MPIFL, respectively); (3) the ventilatory reserve (VRL= 15-s LMV - VEr; VEr= minute volume at rest). Mass specific (s) values were also calculated. All SV changed linearly with somatic growth in both Friesian and BWB calves. Since the rise in SV was more related to body weight than the age of calves, equations for reference values of SV always had body weight as the only independent variable. In the youngest calves, s SV were lower in the BWB breed. In the oldest calves (i.e. 1 year of age), s MPEFLand s MPIFLremained small in BWB calves whereas s MVTL, s 15-s LMV and s VRLwere almost equal in both breeds. These results could be related to the lower resistance to respiratory disorders in BWB calves < 1 year of age than in Friesian calves < 1 year of age.
（1）建立原创方程以预测1岁以下健康弗里斯兰犊牛和比利时白蓝花（BWB）犊牛的肺功能变量（SV）；（2）确定体细胞生长对SV的影响。对67头弗里斯兰犊牛和500头BWB犊牛进行了研究。对于每头犊牛，计算以下SV：（1）使用静脉注射洛贝林（0.25mg/kg）诱导的最大通气变化的15秒内记录的所有通气周期得出的平均分钟通气量（15秒LMV）；（2）洛贝林给药后单次呼吸记录的最大潮气量、最大呼气峰流速和最大吸气峰流速（分别为MVTL、MPEFL和MPIFL）；（3）通气储备（VRL = 15秒LMV - VEr；VEr = 静息分钟通气量）。还计算了质量比（s）值。在弗里斯兰犊牛和BWB犊牛中，所有SV均随体细胞生长呈线性变化。由于SV的增加与犊牛体重的关系比与年龄的关系更大，因此SV参考值的方程始终以体重作为唯一自变量。在最年幼的犊牛中，BWB品种的s SV较低。在最年长的犊牛（即1岁）中，BWB犊牛的s MPEFL和s MPIFL仍然较小，而两个品种的s MVTL、s 15秒LMV和s VRL几乎相等。这些结果可能与1岁以下BWB犊牛比1岁以下弗里斯兰犊牛对呼吸系统疾病的抵抗力较低有关。
