Xiang Y, Moss B
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892-0445, USA.
Virology. 1999 May 10;257(2):297-302. doi: 10.1006/viro.1999.9676.
Molluscum contagiosum virus (MCV) is a human poxvirus that produces small, benign skin tumors primarily in young children and encodes proteins that modulate the host immune response. The MC51L, MC53L, and MC54L open reading frames of MCV have significant amino acid sequence similarities and related proteins are encoded by other poxviruses. These three MCV genes were individually expressed in mammalian cells as glycosylated and secreted proteins. A database search detected partial sequences of homologous human and mouse cDNAs; determination of the complete sequences confirmed the homology and indicated potential signal peptides and N-glycosylation sites as well as a pattern of cysteines that are conserved in the viral proteins. The human gene, which was mapped to chromosome 11q13, was highly expressed in spleen and lymph nodes, suggesting an immune modulatory role. The latter finding is consistent with a recent report (Novick et al., 1999, Immunity 10, 127-136) that the human protein binds IL-18, suggesting an anti-inflammatory role for the poxvirus homologs.
传染性软疣病毒（MCV）是一种人类痘病毒，主要在幼儿中产生小的良性皮肤肿瘤，并编码调节宿主免疫反应的蛋白质。MCV的MC51L、MC53L和MC54L开放阅读框具有显著的氨基酸序列相似性，其他痘病毒也编码相关蛋白质。这三个MCV基因在哺乳动物细胞中分别表达为糖基化和分泌蛋白。数据库搜索检测到同源人类和小鼠cDNA的部分序列；完整序列的确定证实了同源性，并表明了潜在的信号肽和N-糖基化位点以及病毒蛋白中保守的半胱氨酸模式。该人类基因定位于染色体11q13，在脾脏和淋巴结中高度表达，提示其具有免疫调节作用。后一发现与最近的一份报告（Novick等人，1999年，《免疫》10，127 - 136）一致，该报告指出人类蛋白结合IL - 18，提示痘病毒同源物具有抗炎作用。
