Gaillard J A
Bull Cancer. 1976 Jan-Mar;63(1):27-40.
The histogenesis of yolk-sac tumors has been explained by a selective cloning for extra-embryonic entoblast amongst totipotent carcinoma stemcells. The diverses appearances of the tumor growths are expressed mainly in the range of cyto-differentiations of entoblastic tissue rather than in their ability to form structures which mimick the yolk-sac. The process is clearly apparent in embryoids which are becoming disorganized and during the course of experimentally induced mouse parietal endodermal carcinoma. The latter's appearance is strong evidence that the laws of specificity are obeyed. Human tumors should be analyzed through human embryology. Some paradoxical aspects emerge occasionally due to the angiogenesic capabilities of the neoplastic vitelline tissue, and to the correlations of this tissue with the stromal vascular response.
卵黄囊瘤的组织发生学已通过在全能癌干细胞中对胚外内胚层进行选择性克隆来解释。肿瘤生长的多样表现主要体现在内胚层组织的细胞分化范围内，而非其形成类似卵黄囊结构的能力。这一过程在逐渐解体的胚状体以及实验诱导的小鼠壁内胚层癌过程中清晰可见。后者的表现有力地证明其遵循特异性规律。人类肿瘤应通过人类胚胎学进行分析。由于肿瘤性卵黄囊组织的血管生成能力，以及该组织与基质血管反应的相关性，偶尔会出现一些矛盾的方面。
