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FOG-2,一种在心脏和大脑中高度富集的GATA转录因子辅助因子。

FOG-2, a heart- and brain-enriched cofactor for GATA transcription factors.

作者信息

Lu J R, McKinsey T A, Xu H, Wang D Z, Richardson J A, Olson E N

机构信息

Departments of Molecular Biology and Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235-9148, USA.

出版信息

Mol Cell Biol. 1999 Jun;19(6):4495-502. doi: 10.1128/MCB.19.6.4495.

Abstract

Members of the GATA family of zinc finger transcription factors have been shown to play important roles in the control of gene expression in a variety of cell types. GATA-1, -2, and -3 are expressed primarily in hematopoietic cell lineages and are required for proliferation and differentiation of multiple hematopoietic cell types, whereas GATA-4, -5, and -6 are expressed in the heart, where they activate cardiac muscle structural genes. Friend of GATA-1 (FOG) is a multitype zinc finger protein that interacts with GATA-1 and serves as a cofactor for GATA-1-mediated transcription. FOG is coexpressed with GATA-1 in developing erythroid and megakaryocyte cell lineages and cooperates with GATA-1 to control erythropoiesis. We describe a novel FOG-related factor, FOG-2, that is expressed predominantly in the developing and adult heart, brain, and testis. FOG-2 interacts with GATA factors, and interaction of GATA-4 and FOG-2 results in either synergistic activation or repression of GATA-dependent cardiac promoters, depending on the specific promoter and the cell type in which they are tested. The properties of FOG-2 suggest its involvement in the control of cardiac and neural gene expression by GATA transcription factors.

摘要

锌指转录因子GATA家族的成员已被证明在多种细胞类型的基因表达调控中发挥重要作用。GATA-1、-2和-3主要在造血细胞谱系中表达,是多种造血细胞类型增殖和分化所必需的,而GATA-4、-5和-6在心脏中表达,它们在心脏中激活心肌结构基因。GATA-1的结合因子(FOG)是一种多类型锌指蛋白,它与GATA-1相互作用,并作为GATA-1介导转录的辅因子。FOG与GATA-1在发育中的红细胞和巨核细胞谱系中共同表达,并与GATA-1协同控制红细胞生成。我们描述了一种新的FOG相关因子FOG-2,它主要在发育中的以及成年的心脏、脑和睾丸中表达。FOG-2与GATA因子相互作用,GATA-4与FOG-2的相互作用根据所检测的特定启动子和细胞类型,导致对GATA依赖的心脏启动子的协同激活或抑制。FOG-2的特性表明它参与了GATA转录因子对心脏和神经基因表达的调控。

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