Collins M D, Mao G E
Department of Environmental Health Sciences, University of California at Los Angeles, School of Public Health 90095-1735, USA.
Annu Rev Pharmacol Toxicol. 1999;39:399-430. doi: 10.1146/annurev.pharmtox.39.1.399.
Either an excess or a deficiency of vitamin A and related compounds (retinoids) causes abnormal morphological development (teratogenesis). Potential retinoid sources come from dietary intake, nutritional supplements, and some therapeutic drugs. Therefore, understanding the mechanisms of retinoid teratogenesis is important. This review first gives an overview of the principles of teratology as they apply to retinoid-induced malformations. It then describes relevant aspects of the biochemical pathway and signal transduction of retinoids. The teratogenic activity of various retinoid compounds, the role of the retinoid receptors, and important toxicokinetic parameters in teratogenesis are reviewed.
维生素A及相关化合物（类视黄醇）过量或缺乏都会导致形态发育异常（致畸作用）。潜在的类视黄醇来源包括饮食摄入、营养补充剂和一些治疗药物。因此，了解类视黄醇致畸作用的机制很重要。本综述首先概述了适用于类视黄醇诱导畸形的致畸学原理。然后描述了类视黄醇的生化途径和信号转导的相关方面。综述了各种类视黄醇化合物的致畸活性、类视黄醇受体的作用以及致畸作用中重要的毒代动力学参数。
Zotero 插件