骨髓瘤的染色体研究

Chromosome studies in myelomatosis.

作者信息

Wurster-Hill D H, McIntyre O R, Cornwell G G

出版信息

Virchows Arch B Cell Pathol. 1978 Nov 17;29(1-2):93-7. doi: 10.1007/BF02899341.

Abstract

Cytogenetic studies of patients with multiple myeloma and plasma cell leukemia have shown that chromosome abnormalities occur in the bone marrow and/or the PHA-stimulated blood of at least half the patients. The abnormalities include numerical and structural aberrations and are highly variable. Hypodiploid modes occur fairly frequently. Addition of material to the long arm of the No. 14 chromosome (14q+ marker) occurs in about 17% of the small series of patients that have been studied with banding so far.

摘要

对多发性骨髓瘤和浆细胞白血病患者的细胞遗传学研究表明，至少半数患者的骨髓和/或经植物血凝素刺激的血液中存在染色体异常。这些异常包括数目和结构畸变，且高度可变。亚二倍体模式相当常见。在目前用显带技术研究的少数患者系列中，约17%的患者出现14号染色体长臂增加物质（14q+标记）。